The intestinal absorption of some dipeptides
نویسندگان
چکیده
منابع مشابه
Intestinal absorption of stereoisomers of dipeptides in the rat.
1. Studies have been made of jejunal absorption rates in vivo in the rat of the stereoisomers of alanylphenylalanine, leucyl-leucine and glycyltryptophan. Absorption rates of L-alanyl-L-phenylalanine were about 200 times those of D-alanyl-D-phenylalanine, L-leucyl-L-leucine about 24 times those of the DD-isomer, and glycyl-L-tryptophan 5 times those of glycyl-D-tryptophan. The mixed DLand LD-is...
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A 30 cm segment of the duodenum, jejunum, or ileum of normal human volunteers was perfused, on separate occasions, with test solutions containing either glycylglycine, free glycine, glycylleucine, or equimolar amounts of free glycine and free leucine. Luminal fluid contained no hydrolytic activity against glycylglycine and minimal activity against glycylleucine. In each intestinal segment, amin...
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1 . The intestinal absorption of carnosine, glycylglycine, glycyl-D-phenylalanine, glycyl-L-phenylalanine, glycyl-L-proline and L-prolylglycine were investigated after intraluminal injection of dipeptide into anaesthetized rats. 2. With all six dipeptides, the intact substance was detected by ion-exchange chromatography in blood samples taken from the superior mesenteric vein. 3. The rate of hy...
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15 صفحه اولInvestigation of Intestinal Absorption of Pyridinones in Rat
Recently, it has been shown that a number of hydroxypyridinones such as 1,2-dimethyl-3-hydroxypyridin-4-one (L1) are useful for the treatment of iron overload in place of desferrioxamine in thalassaemic patients. In this study, the intestinal absorption (I.A.) of L1 and one of its analogues namely 2-methy-3-hydroxypyridin-4-one (L2), which possesses a higher partition coefficient (Kpart) than L...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1959
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1959.sp006125